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pentobarbital will minimize the level or result of zonisamide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Not known.pentobarbital will lower the extent or effect of ixabepilone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.Check Intently (one)pentobarbital will reduce the level